Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc. - ROEverified

IONS

Price:

$74.12

Market Cap:

$12.25B

Founded in 1989 and headquartered in Carlsbad, California, Ionis Pharmaceuticals, Inc. is a biopharmaceutical company specializing in the discovery and development of RNA-targeted therapies within the United States. Its commercial portfolio includes three key medications: SPINRAZA, prescribed for spinal muscular atrophy (SMA) in both children and adults; TEGSEDI, an injectable treatment targeting polyneuropathy associated with hereditary transthyretin-mediated amyloidosis in adult patients; and WAYLIVRA, which addresses familial chylomicronemia syndrome and familial partial lipodystrophy. Ionis also maintains a robust pipeline, with several drug candidates currently in Phase 3 clinical trial...[Read more]

Industry

Biotechnology

IPO Date

1991-05-17

Stock Exchange

NASDAQ

Ticker

IONS

The ROE as of June 2026 (TTM) for Ionis Pharmaceuticals, Inc. (IONS) is -58.57%

According to Ionis Pharmaceuticals, Inc.’s latest financial reports and current stock price. The company's current ROE is -58.57%. This represents a change of 250.20% compared to the average of -16.73% of the last 4 quarters.

Ionis Pharmaceuticals, Inc. (IONS) Historical ROE (quarterly & annually)

How has IONS ROE performed in the past?

The mean historical ROE of Ionis Pharmaceuticals, Inc. over the last ten years is -37.58%. The current -58.57% ROE has changed 55.85% with respect to the historical average. Over the past ten years (40 quarters), IONS's ROE was at its highest in in the December 2018 quarter at 30.54%. The ROE was at its lowest in in the June 2016 quarter at -51.12%.

Quarterly (TTM)
Annual

Average

-37.58%

Median

-53.43%

Minimum

-94.72%

Maximum

26.12%

Ionis Pharmaceuticals, Inc. (IONS) ROE by Quarter and Year

Discovering the peaks and valleys of Ionis Pharmaceuticals, Inc. ROE, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 21.11%

Maximum Annual ROE = 26.12%

Minimum Annual Increase = -416.12%

Minimum Annual ROE = -94.72%

Quarterly (TTM)
Annual
YearROEChange
2025-77.90%0.98%
2024-77.15%-18.56%
2023-94.72%101.19%
2022-47.08%1.17%
2021-3.71%-93.80%
2020-59.77%-416.12%
201918.91%-27.61%
201826.12%21.11%
20170.12%-100.20%
2016-60.66%37.98%

Ionis Pharmaceuticals, Inc. (IONS) Average ROE

How has IONS ROE performed in the past?

The current ROE of Ionis Pharmaceuticals, Inc. (IONS) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

3-year avg

-83.26%

5-year avg

-60.11%

10-year avg

-37.58%

Ionis Pharmaceuticals, Inc. (IONS) ROE vs. Peers

How is IONS’s ROE compared to its peers?

Ionis Pharmaceuticals, Inc.’s ROE is greater than Ascendis Pharma A/S (-5641.90%), less than BridgeBio Pharma, Inc. (36.00%), greater than Revolution Medicines, Inc. (-83.22%), greater than Roivant Sciences Ltd. (-6.85%), greater than Summit Therapeutics Inc. (-340.55%), less than BioMarin Pharmaceutical Inc. (4.41%), less than Exelixis, Inc. (40.21%), greater than Madrigal Pharmaceuticals, Inc. (-50.15%), greater than Moderna, Inc. (-36.73%), less than Guardant Health, Inc. (184.27%),

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