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NASDAQ · IONSBiotechnologyUpdated Nov 4, 2026

Ionis Pharmaceuticals, Inc. ROE

Profitability, historical returns, and peer comparisons.

The ROE as of November 2026 (TTM) for Ionis Pharmaceuticals, Inc. (IONS) is -110.84%

According to Ionis Pharmaceuticals, Inc.’s latest financial reports and current stock price. The company's current ROE is -110.84%. This represents a change of 293.98% compared to the average of -28.13% of the last 4 quarters.

Ionis Pharmaceuticals, Inc. (IONS) Historical ROE (quarterly & annually)

How has IONS ROE performed in the past?

The mean historical ROE of Ionis Pharmaceuticals, Inc. over the last ten years is -37.58%. The current -110.84% ROE has changed 194.91% with respect to the historical average. Over the past ten years (40 quarters), IONS's ROE was at its highest in in the December 2018 quarter at 30.54%. The ROE was at its lowest in in the March 2024 quarter at -48.16%.

Quarterly (TTM)
Annual

Average

-37.58%

Median

-53.43%

Minimum

-94.72%

Maximum

26.12%

Ionis Pharmaceuticals, Inc. (IONS) ROE by Quarter and Year

Discovering the peaks and valleys of Ionis Pharmaceuticals, Inc. ROE, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 21.11%

Maximum Annual ROE = 26.12%

Minimum Annual Increase = -416.12%

Minimum Annual ROE = -94.72%

Quarterly (TTM)
Annual
YearROEChange
2025-77.90%0.98%
2024-77.15%-18.56%
2023-94.72%101.19%
2022-47.08%1.17%
2021-3.71%-93.80%
2020-59.77%-416.12%
201918.91%-27.61%
201826.12%21.11%
20170.12%-100.20%
2016-60.66%37.98%

Ionis Pharmaceuticals, Inc. (IONS) Average ROE

How has IONS ROE performed in the past?

The current ROE of Ionis Pharmaceuticals, Inc. (IONS) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

3-year avg

-83.26%

5-year avg

-60.11%

10-year avg

-37.58%

Ionis Pharmaceuticals, Inc. (IONS) ROE vs. Peers

How is IONS’s ROE compared to its peers?

Ionis Pharmaceuticals, Inc.’s ROE is less than Alnylam Pharmaceuticals, Inc. (159.72%), less than Biogen Inc. (1.86%), less than Ultragenyx Pharmaceutical Inc. (213.22%), less than BioMarin Pharmaceutical Inc. (-0.31%), less than PTC Therapeutics, Inc. (57.10%), greater than Sarepta Therapeutics, Inc. (-9.96%), greater than Intellia Therapeutics, Inc. (-57.79%), less than BridgeBio Pharma, Inc. (26.76%),

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