The PE Ratio as of December 2025 (TTM) for Ionis Pharmaceuticals, Inc. (IONS) is -50.50

According to Ionis Pharmaceuticals, Inc.’s latest financial reports and current stock price. The company's current PE Ratio is -50.50. This represents a change of 538.23% compared to the average of -7.91 of the last 4 quarters.

Ionis Pharmaceuticals, Inc. (IONS) Historical PE Ratio (quarterly & annually)

How has IONS PE Ratio performed in the past?

The mean historical PE Ratio of Ionis Pharmaceuticals, Inc. over the last ten years is 1.77K. The current -50.50 PE Ratio has changed -385.52% with respect to the historical average. Over the past ten years (40 quarters), IONS's PE Ratio was at its highest in in the December 2017 quarter at 571.59. The PE Ratio was at its lowest in in the June 2019 quarter at -2593.61.

Ionis Pharmaceuticals, Inc. (IONS) PE Ratio by Quarter and Year

Discovering the peaks and valleys of Ionis Pharmaceuticals, Inc. PE Ratio, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Ionis Pharmaceuticals, Inc. (IONS) Average PE Ratio

How has IONS PE Ratio performed in the past?

The current PE Ratio of Ionis Pharmaceuticals, Inc. (IONS) is less than than its 3-year, less than than its 5-year, and less than than its 10-year historical averages

Ionis Pharmaceuticals, Inc. (IONS) PE Ratio vs. Peers

How is IONS’s PE Ratio compared to its peers?

Ionis Pharmaceuticals, Inc.’s PE Ratio is less than Ascendis Pharma A/S (-39.87), less than BridgeBio Pharma, Inc. (-17.87), less than Revolution Medicines, Inc. (-15.45), less than Roivant Sciences Ltd. (-38.57), less than Summit Therapeutics Inc. (-15.17), less than BioMarin Pharmaceutical Inc. (19.86), less than Exelixis, Inc. (17.57), less than Madrigal Pharmaceuticals, Inc. (-46.18), less than Moderna, Inc. (-3.19), less than Guardant Health, Inc. (-33.96),

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