Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.verified




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Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of TTR amyloidosis; Olezarsen for patients with severe hypertriglyceridemia (SHTG); Donidalorsen for patients with ...[Read more]



IPO Date


Stock Exchange




The PE Ratio as of June 2024 (TTM) for Ionis Pharmaceuticals, Inc. (IONS) is -15.22

According to Ionis Pharmaceuticals, Inc.’s latest financial reports and current stock price. The company's current PE Ratio is -15.22. This represents a change of -74.22% compared to the average of -59.03 of the last 4 quarters.

Ionis Pharmaceuticals, Inc. (IONS) Historical PE Ratio (quarterly & annually)

How has IONS PE Ratio performed in the past?

The mean historical PE Ratio of Ionis Pharmaceuticals, Inc. over the last ten years is -153.06. The current -15.22 PE Ratio has changed 894.36% with respect to the historical average. Over the past ten years (40 quarters), IONS's PE Ratio was at its highest in in the December 2017 quarter at 572.01. The PE Ratio was at its lowest in in the June 2019 quarter at -2272.00.

Quarterly (TTM)









Ionis Pharmaceuticals, Inc. (IONS) PE Ratio by Quarter and Year

Discovering the peaks and valleys of Ionis Pharmaceuticals, Inc. PE Ratio, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 1.47%

Maximum Annual PE Ratio = 28.77

Minimum Annual Increase = -156.35%

Minimum Annual PE Ratio = -1044.89

Quarterly (TTM)
YearPE RatioChange

Ionis Pharmaceuticals, Inc. (IONS) Average PE Ratio

How has IONS PE Ratio performed in the past?

The current PE Ratio of Ionis Pharmaceuticals, Inc. (IONS) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

3-year avg


5-year avg


10-year avg


Ionis Pharmaceuticals, Inc. (IONS) PE Ratio vs. Peers

How is IONS’s PE Ratio compared to its peers?

Ionis Pharmaceuticals, Inc.’s PE Ratio is less than Arrowhead Pharmaceuticals, Inc. (0), less than BioMarin Pharmaceutical Inc. (-6.17), less than Incyte Corporation (77.36), less than Apellis Pharmaceuticals, Inc. (18.50), less than Viking Therapeutics, Inc. (-11.81), greater than Intercept Pharmaceuticals, Inc. (-55.90), less than Terns Pharmaceuticals, Inc. (-13.55), less than Akero Therapeutics, Inc. (-6.02), less than Reata Pharmaceuticals, Inc. (-7.33), greater than Seagen Inc. (-89.36), greater than Alnylam Pharmaceuticals, Inc. (-57.36), greater than Exelixis, Inc. (-58.44), less than Halozyme Therapeutics, Inc. (31.62), less than PTC Therapeutics, Inc. (20.02), less than Krystal Biotech, Inc. (-4.70), less than Sarepta Therapeutics, Inc. (85.64), less than Iovance Biotherapeutics, Inc. (653.71), less than Madrigal Pharmaceuticals, Inc. (-4.74), less than null (-12.43),

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