The PE Ratio as of December 2025 (TTM) for Sionna Therapeutics, Inc. (SION) is -22.71

According to Sionna Therapeutics, Inc.’s latest financial reports and current stock price. The company's current PE Ratio is -22.71. This represents a change of 159.61% compared to the average of -8.75 of the last 4 quarters.

Sionna Therapeutics, Inc. (SION) Historical PE Ratio (quarterly & annually)

How has SION PE Ratio performed in the past?

The mean historical PE Ratio of Sionna Therapeutics, Inc. over the last ten years is -22.88. The current -22.71 PE Ratio has changed 9.83% with respect to the historical average. Over the past ten years (40 quarters), SION's PE Ratio was at its highest in in the September 2024 quarter at 0. The PE Ratio was at its lowest in in the June 2024 quarter at -32.25.

Sionna Therapeutics, Inc. (SION) PE Ratio by Quarter and Year

Discovering the peaks and valleys of Sionna Therapeutics, Inc. PE Ratio, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Sionna Therapeutics, Inc. (SION) Average PE Ratio

How has SION PE Ratio performed in the past?

The current PE Ratio of Sionna Therapeutics, Inc. (SION) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

Sionna Therapeutics, Inc. (SION) PE Ratio vs. Peers

How is SION’s PE Ratio compared to its peers?

Sionna Therapeutics, Inc.’s PE Ratio is less than Janux Therapeutics, Inc. (-9.98), less than AbCellera Biologics Inc. (-6.35), less than Maze Therapeutics, Inc. (-15.46), less than Biohaven Ltd. (-1.30), less than Celldex Therapeutics, Inc. (-9.85), less than Vera Therapeutics, Inc. (-12.45), greater than Xeris Biopharma Holdings, Inc. (-32.76), less than Zymeworks Inc. (-0.10), greater than Ardelyx, Inc. (-25.33), less than Immunome, Inc. (-8.23),

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