Denali Therapeutics Inc.

Denali Therapeutics Inc.verified




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Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutic candidates for neurodegenerative diseases in the United States. It offers leucine-rich repeat kinase 2 (LRRK2) inhibitor product candidate, including BIIB122/DNL151, a small molecule inhibitor, which is in phase I and phase Ib clinical trials for the treatment of Parkinson's disease. The company also develops DNL310 that is in Phase I/II clinical trials for the treatment of hunter syndrome; DNL343, which is in phase 1 clinical trial the treatment of amyotrophic lateral sclerosis (ALS); AR443820/DNL788 completed a phase I clinical trial for the treatment of ALS, multiple sclerosis (MS), and Alzheimer's d...[Read more]



IPO Date


Stock Exchange




The PE Ratio as of May 2024 (TTM) for Denali Therapeutics Inc. (DNLI) is -20.44

According to Denali Therapeutics Inc.’s latest financial reports and current stock price. The company's current PE Ratio is -20.44. This represents a change of 431.49% compared to the average of -3.85 of the last 4 quarters.

Denali Therapeutics Inc. (DNLI) Historical PE Ratio (quarterly & annually)

How has DNLI PE Ratio performed in the past?

The mean historical PE Ratio of Denali Therapeutics Inc. over the last ten years is 1.04. The current -20.44 PE Ratio has changed -197145.27% with respect to the historical average. Over the past ten years (40 quarters), DNLI's PE Ratio was at its highest in in the December 2020 quarter at 10.27. The PE Ratio was at its lowest in in the June 2021 quarter at -39.19.

Quarterly (TTM)









Denali Therapeutics Inc. (DNLI) PE Ratio by Quarter and Year

Discovering the peaks and valleys of Denali Therapeutics Inc. PE Ratio, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 1.89%

Maximum Annual PE Ratio = 128.31

Minimum Annual Increase = -1622.46%

Minimum Annual PE Ratio = -52.80

Quarterly (TTM)
YearPE RatioChange

Denali Therapeutics Inc. (DNLI) Average PE Ratio

How has DNLI PE Ratio performed in the past?

The current PE Ratio of Denali Therapeutics Inc. (DNLI) is less than than its 3-year, less than than its 5-year, and less than than its 10-year historical averages

3-year avg


5-year avg


10-year avg


Denali Therapeutics Inc. (DNLI) PE Ratio vs. Peers

How is DNLI’s PE Ratio compared to its peers?

Denali Therapeutics Inc.’s PE Ratio is less than Homology Medicines, Inc. (-0.01), less than Stoke Therapeutics, Inc. (-6.14), less than Atreca, Inc. (-0.04), less than Black Diamond Therapeutics, Inc. (-3.18), less than 4D Molecular Therapeutics, Inc. (-11.85), less than Ascendis Pharma A/S (-13.63), less than Apellis Pharmaceuticals, Inc. (-11.97), greater than BeiGene, Ltd. (-26.39), less than Akero Therapeutics, Inc. (-6.06), greater than Blueprint Medicines Corporation (-21.96), less than Legend Biotech Corporation (-16.18), less than Vaxcyte, Inc. (-17.58), less than Travere Therapeutics, Inc. (-2.95), less than Cerevel Therapeutics Holdings, Inc. (-16.30), less than Avidity Biosciences, Inc. (-10.47), less than Revolution Medicines, Inc. (-12.91), less than Day One Biopharmaceuticals, Inc. (-5.71), less than SpringWorks Therapeutics, Inc. (-9.22), less than Monte Rosa Therapeutics, Inc. (-1.85), less than Design Therapeutics, Inc. (-4.20), less than Werewolf Therapeutics, Inc. (-4.88), less than Ikena Oncology, Inc. (-0.92),

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