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NASDAQ · ZYMEBiotechnologyUpdated Nov 2, 2026

Zymeworks Inc. ROE

Profitability, historical returns, and peer comparisons.

The ROE as of November 2026 (TTM) for Zymeworks Inc. (ZYME) is -72.07%

According to Zymeworks Inc.’s latest financial reports and current stock price. The company's current ROE is -72.07%. This represents a change of 175.90% compared to the average of -26.12% of the last 4 quarters.

Zymeworks Inc. (ZYME) Historical ROE (quarterly & annually)

How has ZYME ROE performed in the past?

The mean historical ROE of Zymeworks Inc. over the last ten years is -61.44%. The current -72.07% ROE has changed 17.30% with respect to the historical average. Over the past ten years (40 quarters), ZYME's ROE was at its highest in in the March 2017 quarter at 177.23%. The ROE was at its lowest in in the December 2016 quarter at -125.27%.

Quarterly (TTM)
Annual

Average

-61.44%

Median

-33.22%

Minimum

-375.57%

Maximum

25.22%

Zymeworks Inc. (ZYME) ROE by Quarter and Year

Discovering the peaks and valleys of Zymeworks Inc. ROE, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 257.33%

Maximum Annual ROE = 25.22%

Minimum Annual Increase = -381.55%

Minimum Annual ROE = -375.57%

Quarterly (TTM)
Annual
YearROEChange
2025-30.22%-16.57%
2024-36.22%41.85%
2023-25.53%-201.22%
202225.22%-129.66%
2021-85.05%93.09%
2020-44.05%-25.60%
2019-59.20%-335.25%
201825.16%-381.55%
2017-8.94%-97.62%
2016-375.57%257.33%

Zymeworks Inc. (ZYME) Average ROE

How has ZYME ROE performed in the past?

The current ROE of Zymeworks Inc. (ZYME) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

3-year avg

-30.66%

5-year avg

-30.36%

10-year avg

-61.44%

Zymeworks Inc. (ZYME) ROE vs. Peers

How is ZYME’s ROE compared to its peers?

Zymeworks Inc.’s ROE is greater than CytomX Therapeutics, Inc. (-38.46%), less than Nurix Therapeutics, Inc. (49.34%), greater than MacroGenics, Inc. (-31.27%), greater than Celldex Therapeutics, Inc. (-52.36%), greater than Xencor, Inc. (-28.66%), greater than Crescent Biopharma, Inc. (-97.77%), greater than Immunome, Inc. (-50.56%), less than ADC Therapeutics S.A. (44.63%), less than Compugen Ltd. (42.57%), greater than ALX Oncology Holdings Inc. (-90.30%),

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