The ROE as of December 2025 (TTM) for Epizyme, Inc. (EPZM) is -305.86%

According to Epizyme, Inc.’s latest financial reports and current stock price. The company's current ROE is -305.86%. This represents a change of 156.71% compared to the average of -119.15% of the last 4 quarters.

Epizyme, Inc. (EPZM) Historical ROE (quarterly & annually)

How has EPZM ROE performed in the past?

The mean historical ROE of Epizyme, Inc. over the last ten years is 75.80%. The current -305.86% ROE has changed -503.51% with respect to the historical average. Over the past ten years (40 quarters), EPZM's ROE was at its highest in in the December 2021 quarter at 244.83%. The ROE was at its lowest in in the March 2022 quarter at -499.10%.

Epizyme, Inc. (EPZM) ROE by Quarter and Year

Discovering the peaks and valleys of Epizyme, Inc. ROE, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Epizyme, Inc. (EPZM) Average ROE

How has EPZM ROE performed in the past?

The current ROE of Epizyme, Inc. (EPZM) is less than than its 3-year, less than than its 5-year, and less than than its 10-year historical averages

Epizyme, Inc. (EPZM) ROE vs. Peers

How is EPZM’s ROE compared to its peers?

Epizyme, Inc.’s ROE is greater than Acelyrin, Inc. (-54.74%), greater than CARGO Therapeutics, Inc. Common Stock (-69.24%), greater than Third Harmonic Bio, Inc. (-19.27%), greater than Inozyme Pharma, Inc. (-159.97%), less than Celularity Inc. (763.31%), greater than Catabasis Pharmaceuticals, Inc. (-24.29%), greater than Spectrum Pharmaceuticals, Inc. (-207.06%), less than 2seventy bio, Inc. (-1.84%), greater than Alaunos Therapeutics, Inc. (-167.97%), greater than Inhibrx Biosciences, Inc. (-186.06%),

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