The PE Ratio as of December 2025 (TTM) for Septerna, Inc. (SEPN) is -3.79

According to Septerna, Inc.’s latest financial reports and current stock price. The company's current PE Ratio is -3.79. This represents a change of -270.65% compared to the average of 2.22 of the last 4 quarters.

Septerna, Inc. (SEPN) Historical PE Ratio (quarterly & annually)

How has SEPN PE Ratio performed in the past?

The mean historical PE Ratio of Septerna, Inc. over the last ten years is 27.19. The current -3.79 PE Ratio has changed -1493.70% with respect to the historical average. Over the past ten years (40 quarters), SEPN's PE Ratio was at its highest in in the September 2025 quarter at 25.51. The PE Ratio was at its lowest in in the March 2024 quarter at -15.86.

Septerna, Inc. (SEPN) PE Ratio by Quarter and Year

Discovering the peaks and valleys of Septerna, Inc. PE Ratio, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Septerna, Inc. (SEPN) Average PE Ratio

How has SEPN PE Ratio performed in the past?

The current PE Ratio of Septerna, Inc. (SEPN) is less than than its 3-year, less than than its 5-year, and less than than its 10-year historical averages

Septerna, Inc. (SEPN) PE Ratio vs. Peers

How is SEPN’s PE Ratio compared to its peers?

Septerna, Inc.’s PE Ratio is greater than Bicara Therapeutics Inc. Common Stock (-9.97), greater than Tango Therapeutics, Inc. (-7.52), less than Fortrea Holdings Inc. (-1.30), less than Prime Medicine, Inc. (-3.13), greater than Kura Oncology, Inc. (-4.84), greater than EyePoint Pharmaceuticals, Inc. (-5.70), greater than ProKidney Corp. (-4.64), greater than Maravai LifeSciences Holdings, Inc. (-4.42), greater than Nurix Therapeutics, Inc. (-6.20), greater than Arbutus Biopharma Corporation (-20.00),

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