Septerna Inc

Septerna Inc - PE Ratioverified

SEPN

Price:

$33.61

Market Cap:

$1.51B

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular di...[Read more]

Industry

Biotechnology

IPO Date

2024-10-25

Stock Exchange

NASDAQ

Ticker

SEPN

The PE Ratio as of July 2026 (TTM) for Septerna Inc (SEPN) is -31.12

According to Septerna Inc’s latest financial reports and current stock price. The company's current PE Ratio is -31.12. This represents a change of 217.12% compared to the average of -9.81 of the last 4 quarters.

Septerna Inc (SEPN) Historical PE Ratio (quarterly & annually)

How has SEPN PE Ratio performed in the past?

The mean historical PE Ratio of Septerna Inc over the last ten years is 174.55. The current -31.12 PE Ratio has changed -1882.91% with respect to the historical average. Over the past ten years (40 quarters), SEPN's PE Ratio was at its highest in in the September 2025 quarter at 26.13. The PE Ratio was at its lowest in in the March 2026 quarter at -31.62.

Quarterly (TTM)
Annual

Average

174.55

Median

-5.93

Minimum

-25.35

Maximum

735.40

Septerna Inc (SEPN) PE Ratio by Quarter and Year

Discovering the peaks and valleys of Septerna Inc PE Ratio, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = Infinity%

Maximum Annual PE Ratio = 735.40

Minimum Annual Increase = -101.61%

Minimum Annual PE Ratio = -25.35

Quarterly (TTM)
Annual
YearPE RatioChange
2025-25.35113.61%
2024-11.87-101.61%
2023735.40Infinity%

Septerna Inc (SEPN) Average PE Ratio

How has SEPN PE Ratio performed in the past?

The current PE Ratio of Septerna Inc (SEPN) is less than than its 3-year, less than than its 5-year, and less than than its 10-year historical averages

3-year avg

232.73

5-year avg

174.55

10-year avg

174.55

Septerna Inc (SEPN) PE Ratio vs. Peers

How is SEPN’s PE Ratio compared to its peers?

Septerna Inc’s PE Ratio is less than Bicara Therapeutics Inc. Common Stock (-9.31), greater than Tango Therapeutics, Inc. (-31.14), less than Fortrea Holdings Inc. (-21.94), less than Prime Medicine, Inc. (-2.39), less than Kura Oncology, Inc. (-2.67), less than EyePoint Pharmaceuticals, Inc. (-3.41), less than ProKidney Corp. (-2.80), less than Maravai LifeSciences Holdings, Inc. (-9.08), less than Nurix Therapeutics, Inc. (-6.84), less than Arbutus Biopharma Corp (5.15),

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