Prime Medicine, Inc.

Prime Medicine, Inc. - PE Ratioverified

PRME

Price:

$3.23

Market Cap:

$583.39M

Prime Medicine, Inc. operates as a biotechnology firm, dedicated to delivering genetic therapies for various diseases by strategically employing advanced gene editing technology. Central to their platform is the "Prime Editor" system, which combines a unique Prime Editor protein—a hybrid composed of a Cas protein and a reverse transcriptase enzyme—with a specialized pegRNA molecule. This pegRNA plays a crucial role by both guiding the Prime Editor to a precise location within the genome and providing the essential template for introducing the desired modification to the target DNA sequence. The company, founded in 2019, maintains its headquarters in Cambridge, Massachusetts.

Industry

Biotechnology

IPO Date

2022-10-20

Stock Exchange

NASDAQ

Ticker

PRME

The PE Ratio as of June 2026 (TTM) for Prime Medicine, Inc. (PRME) is -2.63

According to Prime Medicine, Inc.’s latest financial reports and current stock price. The company's current PE Ratio is -2.63. This represents a change of -14.39% compared to the average of -3.07 of the last 4 quarters.

Prime Medicine, Inc. (PRME) Historical PE Ratio (quarterly & annually)

How has PRME PE Ratio performed in the past?

The mean historical PE Ratio of Prime Medicine, Inc. over the last ten years is -120.94. The current -2.63 PE Ratio has changed 117.46% with respect to the historical average. Over the past ten years (40 quarters), PRME's PE Ratio was at its highest in in the March 2025 quarter at -1.25. The PE Ratio was at its lowest in in the December 2019 quarter at -145.55.

Quarterly (TTM)
Annual

Average

-120.94

Median

-7.99

Minimum

-526.37

Maximum

-1.77

Prime Medicine, Inc. (PRME) PE Ratio by Quarter and Year

Discovering the peaks and valleys of Prime Medicine, Inc. PE Ratio, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 59.15%

Maximum Annual PE Ratio = -1.77

Minimum Annual Increase = -97.25%

Minimum Annual PE Ratio = -526.37

Quarterly (TTM)
Annual
YearPE RatioChange
2025-2.5745.38%
2024-1.77-56.54%
2023-4.07-68.01%
2022-12.7259.15%
2021-7.99-97.25%
2020-291.10-44.70%

Prime Medicine, Inc. (PRME) Average PE Ratio

How has PRME PE Ratio performed in the past?

The current PE Ratio of Prime Medicine, Inc. (PRME) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

3-year avg

-2.80

5-year avg

-5.82

10-year avg

-120.94

Prime Medicine, Inc. (PRME) PE Ratio vs. Peers

How is PRME’s PE Ratio compared to its peers?

Prime Medicine, Inc.’s PE Ratio is greater than Maravai LifeSciences Holdings, Inc. (-7.17), greater than Kura Oncology, Inc. (-2.96), greater than Bicara Therapeutics Inc. Common Stock (-8.36), greater than Vir Biotechnology, Inc. (-2.93), greater than Replimune Group, Inc. (-2.85), greater than Septerna, Inc. (-44.65), greater than Tyra Biosciences, Inc. (-12.99), greater than ProKidney Corp. (-3.33), greater than Rezolute, Inc. (-6.12), greater than EyePoint Pharmaceuticals, Inc. (-3.88),

Build a custom stock screener for Prime Medicine, Inc. (PRME) and other stocks

One of the best ways to find valuable stocks to invest in is to build a custom made screener in your Excel or Google Sheets spreadsheet. This allows you to compare thousands of companies like Prime Medicine, Inc. using the financials and key metrics that matter to you in a single view.

The easiest way to set this up is to use the Wisesheets add-on and set your spreadsheet like this:

Custom stock screener in Wisesheets

Covering all these metrics from financial, data, dividend data, key metrics and more you can get all the data you want for over 50+ exchanges worldwide.

Get your free trial here.

Prime Medicine, Inc. (PRME) and other stocks custom spreadsheet templates

The easiest way to analyze a company like Prime Medicine, Inc. or any others is to create a spreadsheet model that automatically retrieves all of the stock data you need.

Using Wisesheets you can set up a spreadsheet model like this with simple spreadsheet formulas. If you change the ticker you can get all of the data automatically updated for you.

Custom stock templates in Wisesheets

Whether you need live data, historical price data, financials, dividend data, key metrics, analyst estimates, or anything else...Wisesheets has you covered.

Frequently asked questions❓

What is the PE Ratio?

How can you use the PE Ratio?

What is Prime Medicine, Inc.'s PE Ratio?

How is the PE Ratio calculated for Prime Medicine, Inc. (PRME)?

What is the highest PE Ratio for Prime Medicine, Inc. (PRME)?

What is the 3-year average PE Ratio for Prime Medicine, Inc. (PRME)?

What is the 5-year average PE Ratio for Prime Medicine, Inc. (PRME)?

How does the current PE Ratio for Prime Medicine, Inc. (PRME) compare to its historical average?