Septerna Inc

Septerna Inc - ROEverified

SEPN

Price:

$33.61

Market Cap:

$1.51B

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular di...[Read more]

Industry

Biotechnology

IPO Date

2024-10-25

Stock Exchange

NASDAQ

Ticker

SEPN

The ROE as of July 2026 (TTM) for Septerna Inc (SEPN) is -9.44%

According to Septerna Inc’s latest financial reports and current stock price. The company's current ROE is -9.44%. This represents a change of 294.69% compared to the average of -2.39% of the last 4 quarters.

Septerna Inc (SEPN) Historical ROE (quarterly & annually)

How has SEPN ROE performed in the past?

The mean historical ROE of Septerna Inc over the last ten years is -10.20%. The current -9.44% ROE has changed -7.39% with respect to the historical average. Over the past ten years (40 quarters), SEPN's ROE was at its highest in in the June 2024 quarter at 24.26%. The ROE was at its lowest in in the June 2025 quarter at -6.58%.

Quarterly (TTM)
Annual

Average

-10.20%

Median

-11.85%

Minimum

-17.09%

Maximum

0%

Septerna Inc (SEPN) ROE by Quarter and Year

Discovering the peaks and valleys of Septerna Inc ROE, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 56.92%

Maximum Annual ROE = 0%

Minimum Annual Increase = -Infinity%

Minimum Annual ROE = -17.09%

Quarterly (TTM)
Annual
YearROEChange
2025-12.80%-25.13%
2024-17.09%56.92%
2023-10.89%-Infinity%

Septerna Inc (SEPN) Average ROE

How has SEPN ROE performed in the past?

The current ROE of Septerna Inc (SEPN) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

3-year avg

-13.59%

5-year avg

-10.20%

10-year avg

-10.20%

Septerna Inc (SEPN) ROE vs. Peers

How is SEPN’s ROE compared to its peers?

Septerna Inc’s ROE is greater than Bicara Therapeutics Inc. Common Stock (-35.89%), greater than Tango Therapeutics, Inc. (-41.54%), greater than Fortrea Holdings Inc. (-15.53%), greater than Prime Medicine, Inc. (-188.82%), greater than Kura Oncology, Inc. (-141.95%), greater than EyePoint Pharmaceuticals, Inc. (-110.54%), less than ProKidney Corp. (7.40%), greater than Maravai LifeSciences Holdings, Inc. (-44.72%), greater than Nurix Therapeutics, Inc. (-76.09%), less than Arbutus Biopharma Corp (129.32%),

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