The ROE as of December 2025 (TTM) for Septerna, Inc. (SEPN) is -14.83%

According to Septerna, Inc.’s latest financial reports and current stock price. The company's current ROE is -14.83%. This represents a change of 301.75% compared to the average of -3.69% of the last 4 quarters.

Septerna, Inc. (SEPN) Historical ROE (quarterly & annually)

How has SEPN ROE performed in the past?

The mean historical ROE of Septerna, Inc. over the last ten years is 11.54%. The current -14.83% ROE has changed -228.45% with respect to the historical average. Over the past ten years (40 quarters), SEPN's ROE was at its highest in in the June 2024 quarter at 24.26%. The ROE was at its lowest in in the December 2023 quarter at -90.93%.

Septerna, Inc. (SEPN) ROE by Quarter and Year

Discovering the peaks and valleys of Septerna, Inc. ROE, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Septerna, Inc. (SEPN) Average ROE

How has SEPN ROE performed in the past?

The current ROE of Septerna, Inc. (SEPN) is less than than its 3-year, less than than its 5-year, and less than than its 10-year historical averages

Septerna, Inc. (SEPN) ROE vs. Peers

How is SEPN’s ROE compared to its peers?

Septerna, Inc.’s ROE is greater than Bicara Therapeutics Inc. Common Stock (-21.67%), greater than Tango Therapeutics, Inc. (-79.72%), greater than Fortrea Holdings Inc. (-119.71%), greater than Prime Medicine, Inc. (-163.51%), greater than Kura Oncology, Inc. (-65.42%), greater than EyePoint Pharmaceuticals, Inc. (-76.13%), less than ProKidney Corp. (11.01%), greater than Maravai LifeSciences Holdings, Inc. (-42.64%), greater than Nurix Therapeutics, Inc. (-53.57%), greater than Arbutus Biopharma Corporation (-50.20%),

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