The PE Ratio as of December 2025 (TTM) for Spruce Biosciences, Inc. (SPRB) is -1.07

According to Spruce Biosciences, Inc.’s latest financial reports and current stock price. The company's current PE Ratio is -1.07. This represents a change of 24.22% compared to the average of -0.00 of the last 4 quarters.

Spruce Biosciences, Inc. (SPRB) Historical PE Ratio (quarterly & annually)

How has SPRB PE Ratio performed in the past?

The mean historical PE Ratio of Spruce Biosciences, Inc. over the last ten years is -0.19. The current -1.07 PE Ratio has changed 55.55% with respect to the historical average. Over the past ten years (40 quarters), SPRB's PE Ratio was at its highest in in the December 2024 quarter at -0.00. The PE Ratio was at its lowest in in the September 2019 quarter at -0.98.

Spruce Biosciences, Inc. (SPRB) PE Ratio by Quarter and Year

Discovering the peaks and valleys of Spruce Biosciences, Inc. PE Ratio, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Spruce Biosciences, Inc. (SPRB) Average PE Ratio

How has SPRB PE Ratio performed in the past?

The current PE Ratio of Spruce Biosciences, Inc. (SPRB) is less than than its 3-year, less than than its 5-year, and less than than its 10-year historical averages

Spruce Biosciences, Inc. (SPRB) PE Ratio vs. Peers

How is SPRB’s PE Ratio compared to its peers?

Spruce Biosciences, Inc.’s PE Ratio is greater than NRx Pharmaceuticals, Inc. (-1.43), less than Werewolf Therapeutics, Inc. (-0.63), greater than Outlook Therapeutics, Inc. (-1.75), less than IO Biotech, Inc. (-0.51), greater than Cue Biopharma, Inc. (-1.36), less than OS Therapies Incorporated (-0.01), greater than vTv Therapeutics Inc. (-9.22), greater than Equillium, Inc. (-2.33), greater than Coeptis Therapeutics, Inc. (-8.96),

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