Upstream Bio, Inc.

Upstream Bio, Inc.verified

UPB

Price:

$6.1

Market Cap:

$331.96M

Upstream Bio, Inc. is a biotechnology company in the clinical development stage, dedicated to innovating therapies for inflammatory conditions, particularly those affecting the severe respiratory system. Its pipeline notably features verekitug, a monoclonal antibody designed to selectively target and suppress the thymic stromal lymphopoietin receptor. Beyond this, the company is actively developing treatments for severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Established in 2021, Upstream Bio maintains its operational base in Waltham, Massachusetts.

Industry

Biotechnology

IPO Date

2024-10-11

Stock Exchange

NASDAQ

Ticker

UPB

The Enterprise Value as of June 2026 (TTM) for Upstream Bio, Inc. (UPB) is 236.35M

According to Upstream Bio, Inc.’s latest financial reports and current stock price. The company's current Enterprise Value is 236.35M. This represents a change of -70.96% compared to the average of 813.96M of the last 4 quarters.

Upstream Bio, Inc. (UPB) Historical Enterprise Value (quarterly & annually)

How has UPB Enterprise Value performed in the past?

The mean historical Enterprise Value of Upstream Bio, Inc. over the last ten years is 859.32M. The current 236.35M Enterprise Value has changed 2.65% with respect to the historical average. Over the past ten years (40 quarters), UPB's Enterprise Value was at its highest in in the December 2025 quarter at 1.37B. The Enterprise Value was at its lowest in in the September 2023 quarter at 0.

Quarterly (TTM)
Annual

Average

859.32M

Median

777.74M

Minimum

520.00M

Maximum

1.36B

Upstream Bio, Inc. (UPB) Enterprise Value by Quarter and Year

Discovering the peaks and valleys of Upstream Bio, Inc. Enterprise Value, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 161.88%

Maximum Annual Enterprise Value = 1.36B

Minimum Annual Increase = -32.76%

Minimum Annual Enterprise Value = 520.00M

Quarterly (TTM)
Annual
YearEnterprise ValueChange
20251.36B161.88%
2024520.00M-32.76%
2023773.33M-1.13%

Upstream Bio, Inc. (UPB) Average Enterprise Value

How has UPB Enterprise Value performed in the past?

The current Enterprise Value of Upstream Bio, Inc. (UPB) is less than than its 3-year, less than than its 5-year, and less than than its 10-year historical averages

3-year avg

885.04M

5-year avg

859.32M

10-year avg

859.32M

Upstream Bio, Inc. (UPB) Enterprise Value vs. Peers

How is UPB’s Enterprise Value compared to its peers?

Upstream Bio, Inc.’s Enterprise Value is less than Zenas BioPharma, Inc. (735.43M), less than Intellia Therapeutics, Inc. (1.30B), less than Wave Life Sciences Ltd. (600.52M), less than Relay Therapeutics, Inc. (2.42B), less than Pharvaris N.V. (1.60B), less than Syndax Pharmaceuticals, Inc. (1.83B), less than Novavax, Inc. (1.53B), less than Amylyx Pharmaceuticals, Inc. (989.29M), less than Terns Pharmaceuticals, Inc. (4.25B), less than Spyre Therapeutics, Inc. (4.78B),

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