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NASDAQ · SPROBiotechnologyUpdated Nov 2, 2026

Spero Therapeutics, Inc. enterprise value

Company valuation, historical trends, and peer comparisons.

The Enterprise Value as of November 2026 (TTM) for Spero Therapeutics, Inc. (SPRO) is 11.25M

According to Spero Therapeutics, Inc.’s latest financial reports and current stock price. The company's current Enterprise Value is 11.25M. This represents a change of -85.64% compared to the average of 78.37M of the last 4 quarters.

Spero Therapeutics, Inc. (SPRO) Historical Enterprise Value (quarterly & annually)

How has SPRO Enterprise Value performed in the past?

The mean historical Enterprise Value of Spero Therapeutics, Inc. over the last ten years is 103.92M. The current 11.25M Enterprise Value has changed -89.17% with respect to the historical average. Over the past ten years (40 quarters), SPRO's Enterprise Value was at its highest in in the September 2021 quarter at 485.93M. The Enterprise Value was at its lowest in in the September 2023 quarter at -24214561.20.

Quarterly (TTM)
Annual

Average

103.92M

Median

64.99M

Minimum

-56892336.25

Maximum

389.39M

Spero Therapeutics, Inc. (SPRO) Enterprise Value by Quarter and Year

Discovering the peaks and valleys of Spero Therapeutics, Inc. Enterprise Value, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 1.22%

Maximum Annual Enterprise Value = 389.39M

Minimum Annual Increase = -213.08%

Minimum Annual Enterprise Value = -56892336.25

Quarterly (TTM)
Annual
YearEnterprise ValueChange
202593.16M1.22%
20247.07M5.73%
20236.68M-117.85%
2022-37437820.25-109.61%
2021389.39M9.17%
2020356.70M136.98%
2019150.52M133.98%
201864.33M-213.08%
2017-56892336.25-186.67%
201665.64M-6.58%

Spero Therapeutics, Inc. (SPRO) Average Enterprise Value

How has SPRO Enterprise Value performed in the past?

The current Enterprise Value of Spero Therapeutics, Inc. (SPRO) is less than than its 3-year, less than than its 5-year, and less than than its 10-year historical averages

3-year avg

35.64M

5-year avg

91.77M

10-year avg

103.92M

Spero Therapeutics, Inc. (SPRO) Enterprise Value vs. Peers

How is SPRO’s Enterprise Value compared to its peers?

Spero Therapeutics, Inc.’s Enterprise Value is less than Seres Therapeutics, Inc. (59.94M), greater than VistaGen Therapeutics, Inc. (-8726055.00), greater than Actuate Therapeutics Inc (4.86M), less than Inovio Pharmaceuticals, Inc. (98.52M), greater than Acumen Pharmaceuticals, Inc. (-8185953.00), less than Seer, Inc. (89.06M), less than Cognition Therapeutics, Inc. (35.91M), less than Opus Genetics, Inc. (248.03M), less than TuHURA Biosciences, Inc. (115.71M), less than Corbus Pharmaceuticals Holdings, Inc. (57.10M),

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