Prothena Corporation plc

Prothena Corporation plcverified

PRTA

Price:

$11.16

Market Cap:

$600.74M

Prothena Corporation plc, a late-stage clinical company, focuses on discovery and development of novel therapies for life-threatening diseases in the United States. The company is involved in developing Birtamimab, an investigational humanized antibody that is in Phase III clinical trial for the treatment of AL amyloidosis; Prasinezumab, a humanized monoclonal antibody, which is in Phase IIb clinical trial for the treatment of Parkinson's disease; PRX004 that completed Phase I clinical trial for the treatment of Transthyretin amyloidosis; and PRX005, which is in Phase I clinical trial for the treatment of Alzheimer's disease. Its discovery and preclinical programs include PRX012 for the trea...[Read more]

Industry

Biotechnology

IPO Date

2012-12-18

Stock Exchange

NASDAQ

Ticker

PRTA

The ROE as of December 2025 (TTM) for Prothena Corporation plc (PRTA) is -72.66%

According to Prothena Corporation plc’s latest financial reports and current stock price. The company's current ROE is -72.66%. This represents a change of 278.34% compared to the average of -19.21% of the last 4 quarters.

Prothena Corporation plc (PRTA) Historical ROE (quarterly & annually)

How has PRTA ROE performed in the past?

The mean historical ROE of Prothena Corporation plc over the last ten years is -29.66%. The current -72.66% ROE has changed 144.99% with respect to the historical average. Over the past ten years (40 quarters), PRTA's ROE was at its highest in in the September 2021 quarter at 22.27%. The ROE was at its lowest in in the June 2025 quarter at -38.78%.

Quarterly (TTM)
Annual

Average

-29.66%

Median

-27.33%

Minimum

-60.40%

Maximum

14.37%

Prothena Corporation plc (PRTA) ROE by Quarter and Year

Discovering the peaks and valleys of Prothena Corporation plc ROE, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 806.18%

Maximum Annual ROE = 14.37%

Minimum Annual Increase = -230.82%

Minimum Annual ROE = -60.40%

Quarterly (TTM)
Annual
YearROEChange
2024-25.12%-4.09%
2023-26.19%39.31%
2022-18.80%-230.82%
202114.37%-123.79%
2020-60.40%112.23%
2019-28.46%-40.94%
2018-48.19%28.05%
2017-37.63%-14.11%
2016-43.82%96.04%
2015-22.35%806.18%

Prothena Corporation plc (PRTA) Average ROE

How has PRTA ROE performed in the past?

The current ROE of Prothena Corporation plc (PRTA) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

3-year avg

-23.37%

5-year avg

-23.23%

10-year avg

-29.66%

Prothena Corporation plc (PRTA) ROE vs. Peers

How is PRTA’s ROE compared to its peers?

Prothena Corporation plc’s ROE is greater than KalVista Pharmaceuticals, Inc. (-195.62%), greater than Bicycle Therapeutics plc (-35.54%), greater than 4D Molecular Therapeutics, Inc. (-47.27%), greater than Verastem, Inc. (-9587.28%), greater than Olema Pharmaceuticals, Inc. (-41.51%), greater than Ventyx Biosciences, Inc. (-48.11%), greater than Neumora Therapeutics, Inc. Common Stock (-113.81%), greater than Corvus Pharmaceuticals, Inc. (-25.78%), greater than Gossamer Bio, Inc. (-1774.72%), less than Rigel Pharmaceuticals, Inc. (204.70%),

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