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NASDAQ · PRTABiotechnologyUpdated Nov 4, 2026

Prothena Corporation plc ROE

Profitability, historical returns, and peer comparisons.

The ROE as of November 2026 (TTM) for Prothena Corporation plc (PRTA) is -14.98%

According to Prothena Corporation plc’s latest financial reports and current stock price. The company's current ROE is -14.98%. This represents a change of 272.20% compared to the average of -4.02% of the last 4 quarters.

Prothena Corporation plc (PRTA) Historical ROE (quarterly & annually)

How has PRTA ROE performed in the past?

The mean historical ROE of Prothena Corporation plc over the last ten years is -36.13%. The current -14.98% ROE has changed -58.55% with respect to the historical average. Over the past ten years (40 quarters), PRTA's ROE was at its highest in in the September 2021 quarter at 22.27%. The ROE was at its lowest in in the June 2025 quarter at -38.78%.

Quarterly (TTM)
Annual

Average

-36.13%

Median

-33.05%

Minimum

-87.03%

Maximum

14.37%

Prothena Corporation plc (PRTA) ROE by Quarter and Year

Discovering the peaks and valleys of Prothena Corporation plc ROE, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 246.47%

Maximum Annual ROE = 14.37%

Minimum Annual Increase = -230.82%

Minimum Annual ROE = -87.03%

Quarterly (TTM)
Annual
YearROEChange
2025-87.03%246.47%
2024-25.12%-4.09%
2023-26.19%39.31%
2022-18.80%-230.82%
202114.37%-123.79%
2020-60.40%112.23%
2019-28.46%-40.94%
2018-48.19%28.05%
2017-37.63%-14.11%
2016-43.82%96.04%

Prothena Corporation plc (PRTA) Average ROE

How has PRTA ROE performed in the past?

The current ROE of Prothena Corporation plc (PRTA) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

3-year avg

-46.11%

5-year avg

-28.55%

10-year avg

-36.13%

Prothena Corporation plc (PRTA) ROE vs. Peers

How is PRTA’s ROE compared to its peers?

Prothena Corporation plc’s ROE is greater than AC Immune S.A. (-99.17%), greater than ProMIS Neurosciences, Inc. (-143.09%), greater than Denali Therapeutics Inc. (-33.98%), greater than Annexon, Inc. (-106.15%), greater than Cognition Therapeutics, Inc. (-50.17%), greater than Neumora Therapeutics, Inc. Common Stock (-242.28%), greater than Acumen Pharmaceuticals, Inc. (-166.49%), less than Biogen Inc. (1.86%), greater than Anavex Life Sciences Corp. (-21.11%),

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