Cortexyme, Inc.

Cortexyme, Inc.verified

CRTX

Price:

$1.95

Market Cap:

$234.42M

Cortexyme, Inc., a clinical stage biopharmaceutical company, focuses on developing therapeutics for Alzheimer's and other degenerative diseases. Its lead drug candidate is atuzaginstat (COR388), an orally administered brain-penetrating small molecule gingipain inhibitor, which is in Phase II/III clinical trial for use in patients with mild to moderate Alzheimer's disease, as well as for the treatment of oral squamous cell carcinoma, periodontitis, and coronavirus infection. The company was incorporated in 2012 and is headquartered in South San Francisco, California.

Industry

Biotechnology

IPO Date

2019-05-09

Stock Exchange

NASDAQ

Ticker

CRTX

The PE Ratio as of December 2025 (TTM) for Cortexyme, Inc. (CRTX) is -0.66

According to Cortexyme, Inc.’s latest financial reports and current stock price. The company's current PE Ratio is -0.66. This represents a change of -50.52% compared to the average of -1.33 of the last 4 quarters.

Cortexyme, Inc. (CRTX) Historical PE Ratio (quarterly & annually)

How has CRTX PE Ratio performed in the past?

The mean historical PE Ratio of Cortexyme, Inc. over the last ten years is -20.18. The current -0.66 PE Ratio has changed 226.12% with respect to the historical average. Over the past ten years (40 quarters), CRTX's PE Ratio was at its highest in in the June 2024 quarter at -0.28. The PE Ratio was at its lowest in in the September 2018 quarter at -70.29.

Quarterly (TTM)
Annual

Average

-20.18

Median

-7.36

Minimum

-57.93

Maximum

-0.41

Cortexyme, Inc. (CRTX) PE Ratio by Quarter and Year

Discovering the peaks and valleys of Cortexyme, Inc. PE Ratio, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 201.43%

Maximum Annual PE Ratio = -0.41

Minimum Annual Increase = -90.09%

Minimum Annual PE Ratio = -57.93

Quarterly (TTM)
Annual
YearPE RatioChange
2024-1.4214.27%
2023-1.25201.43%
2022-0.41-90.09%
2021-4.17-60.46%
2020-10.55-63.50%
2019-28.89-49.15%
2018-56.81-1.93%

Cortexyme, Inc. (CRTX) Average PE Ratio

How has CRTX PE Ratio performed in the past?

The current PE Ratio of Cortexyme, Inc. (CRTX) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

3-year avg

-1.03

5-year avg

-3.56

10-year avg

-20.18

Cortexyme, Inc. (CRTX) PE Ratio vs. Peers

How is CRTX’s PE Ratio compared to its peers?

Cortexyme, Inc.’s PE Ratio is greater than Surface Oncology, Inc. (-0.91), greater than Achilles Therapeutics plc (-1.66), greater than Landos Biopharma, Inc. (-6.56), greater than Jade Biosciences, Inc. (-9.09), less than Reneo Pharmaceuticals, Inc. (73.07), greater than IGM Biosciences, Inc. (-1.46), less than TCR2 Therapeutics Inc. (-0.38), greater than Kronos Bio, Inc. (-0.83), less than Heat Biologics, Inc. (-0.00), greater than Berkeley Lights, Inc. (-0.84),

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