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NASDAQ · KPTIBiotechnologyUpdated Nov 2, 2026

Karyopharm Therapeutics Inc. enterprise value

Company valuation, historical trends, and peer comparisons.

The Enterprise Value as of November 2026 (TTM) for Karyopharm Therapeutics Inc. (KPTI) is 163.31M

According to Karyopharm Therapeutics Inc.’s latest financial reports and current stock price. The company's current Enterprise Value is 163.31M. This represents a change of -42.92% compared to the average of 286.10M of the last 4 quarters.

Karyopharm Therapeutics Inc. (KPTI) Historical Enterprise Value (quarterly & annually)

How has KPTI Enterprise Value performed in the past?

The mean historical Enterprise Value of Karyopharm Therapeutics Inc. over the last ten years is 501.83M. The current 163.31M Enterprise Value has changed -67.46% with respect to the historical average. Over the past ten years (40 quarters), KPTI's Enterprise Value was at its highest in in the June 2020 quarter at 1.41B. The Enterprise Value was at its lowest in in the March 2025 quarter at 179.60M.

Quarterly (TTM)
Annual

Average

501.83M

Median

346.71M

Minimum

214.43M

Maximum

1.18B

Karyopharm Therapeutics Inc. (KPTI) Enterprise Value by Quarter and Year

Discovering the peaks and valleys of Karyopharm Therapeutics Inc. Enterprise Value, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 129.00%

Maximum Annual Enterprise Value = 1.18B

Minimum Annual Increase = -59.19%

Minimum Annual Enterprise Value = 214.43M

Quarterly (TTM)
Annual
YearEnterprise ValueChange
2025253.55M18.24%
2024214.43M-4.11%
2023223.62M-30.60%
2022322.25M-31.87%
2021473.02M-59.19%
20201.16B-1.97%
20191.18B129.00%
2018516.29M39.09%
2017371.18M22.63%
2016302.68M-26.76%

Karyopharm Therapeutics Inc. (KPTI) Average Enterprise Value

How has KPTI Enterprise Value performed in the past?

The current Enterprise Value of Karyopharm Therapeutics Inc. (KPTI) is less than than its 3-year, less than than its 5-year, and less than than its 10-year historical averages

3-year avg

230.53M

5-year avg

297.37M

10-year avg

501.83M

Karyopharm Therapeutics Inc. (KPTI) Enterprise Value vs. Peers

How is KPTI’s Enterprise Value compared to its peers?

Karyopharm Therapeutics Inc.’s Enterprise Value is greater than Senti Biosciences, Inc. (19.20M), greater than Barinthus Biotherapeutics plc (-18767734.00), greater than CEL-SCI Corporation (26.50M), less than X4 Pharmaceuticals, Inc. (221.71M), greater than Aligos Therapeutics, Inc. (3.16M), greater than FibroGen, Inc. (-32139522.00), greater than INmune Bio, Inc. (23.51M), greater than Mersana Therapeutics, Inc. (91.27M), greater than Medicus Pharma Ltd. Common Stock (7.15M), greater than Telomir Pharmaceuticals, Inc. Common Stock (64.40M),

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Frequently asked questions❓

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How does the current Enterprise Value for Karyopharm Therapeutics Inc. (KPTI) compare to its historical average?