Zynerba Pharmaceuticals, Inc.

Zynerba Pharmaceuticals, Inc.verified

0M40.L

Zynerba Pharmaceuticals, Inc. operates as a clinical stage specialty pharmaceutical company. The company focuses on developing pharmaceutically-produced transdermal cannabinoid therapies for rare and near-rare neuropsychiatric disorders. It is developing Zygel, a pharmaceutically-produced cannabidiol formulated as a permeation-enhanced gel for transdermal delivery. The company was formerly known as AllTranz, Inc. and changed its name to Zynerba Pharmaceuticals, Inc. in August 2014. Zynerba Pharmaceuticals, Inc. was incorporated in 2007 and is headquartered in Devon, Pennsylvania.

Industry

Medical - Pharmaceuticals

IPO Date

2018-01-29

Stock Exchange

LSE

Ticker

0M40.L

The ROE as of November 2025 (TTM) for Zynerba Pharmaceuticals, Inc. (0M40.L) is -59.45%

According to Zynerba Pharmaceuticals, Inc.’s latest financial reports and current stock price. The company's current ROE is -59.45%. This represents a change of 149.16% compared to the average of -23.86% of the last 4 quarters.

Zynerba Pharmaceuticals, Inc. (0M40.L) Historical ROE (quarterly & annually)

How has 0M40.L ROE performed in the past?

The mean historical ROE of Zynerba Pharmaceuticals, Inc. over the last ten years is -36.26%. The current -59.45% ROE has changed 63.96% with respect to the historical average. Over the past ten years (40 quarters), 0M40.L's ROE was at its highest in in the December 2014 quarter at 17.44%. The ROE was at its lowest in in the June 2023 quarter at -37.13%.

Quarterly (TTM)
Annual

Average

-36.26%

Median

-52.77%

Minimum

-83.81%

Maximum

70.41%

Zynerba Pharmaceuticals, Inc. (0M40.L) ROE by Quarter and Year

Discovering the peaks and valleys of Zynerba Pharmaceuticals, Inc. ROE, unveiling quarterly and yearly fluctuations to gain insights into the company’s financial performance and market dynamics, offering valuable data for investors and analysts alike.

Maximum Annual Increase = 150.07%

Maximum Annual ROE = 70.41%

Minimum Annual Increase = -144.89%

Minimum Annual ROE = -83.81%

Quarterly (TTM)
Annual
YearROEChange
2022-75.32%42.05%
2021-53.02%-36.73%
2020-83.81%101.55%
2019-41.58%-39.99%
2018-69.29%31.92%
2017-52.52%-33.56%
2016-79.05%150.07%
2015-31.61%-144.89%
201470.41%32.33%

Zynerba Pharmaceuticals, Inc. (0M40.L) Average ROE

How has 0M40.L ROE performed in the past?

The current ROE of Zynerba Pharmaceuticals, Inc. (0M40.L) is greater than its 3-year, greater than its 5-year, and greater than its 10-year historical averages

3-year avg

-70.72%

5-year avg

-64.60%

10-year avg

-36.26%

Zynerba Pharmaceuticals, Inc. (0M40.L) ROE vs. Peers

How is 0M40.L’s ROE compared to its peers?

Zynerba Pharmaceuticals, Inc.’s ROE is less than bluebird bio, Inc. (1.90%), less than MD Medical Group Investments Plc (18.39%), less than Endo International plc (45.54%), greater than Unity Biotechnology, Inc. (-273.74%), greater than Invitae Corporation (-201.69%), less than Palatin Technologies, Inc. (112.10%), greater than Cara Therapeutics, Inc. (-115.90%), less than Accelerate Diagnostics, Inc. (77.07%), greater than Imunon, Inc. (-336.51%), greater than VivoSim Labs, Inc. (-33.01%),

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